Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1
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چکیده
منابع مشابه
16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway.
Angiogenesis plays a key role in promoting tumorigenesis and metastasis. The 16-kDa fragment of prolactin (16k PRL) is an NH(2)-terminal natural breakdown fragment of the intact 23-kDa prolactin and has been shown to have potent antiangiogenic and antitumor activities. The mechanism(s) involved in the action of 16k PRL in endothelial cells remains unclear. In this study, we showed that 16k PRL ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2014
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvu236